Structural similarities to clonidine Lofexidine

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structure of clonidine , lofexidine


lofexidine structurally analogous clonidine, α2 adrenergic receptor agonist used treatment of opioid withdrawal symptoms. comparison of 2 structures shown @ right. both contain imidazole ring , 2,6-dichlorinated phenyl ring. differences in structure shown in red, while similarities in black. in addition structural differences, administration of lofexidine in heroin addicts has been shown more effective longer duration, fewer withdrawal symptoms clonidine after 1 day. however, clonidine preferred substantially cheaper lofexidine when purchased private (non-nhs) prescription. factor exacerbated considerable number of , quantities of medications prescribed alleviate constellation of withdrawal signs , symptoms. additionally, clonidine has been shown lower blood pressure. therefore, although similar lofexidine, clonidine prescribed treat high blood pressure.








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