Immunological genome project Immunomics

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the immune system network of genetic , signaling pathways connected network of interacting cells. immunological genome project seeks generate complete compendium of protein-coding gene expression cell populations in mouse immune system. analyzes both steady-state conditions within different cell populations, , in response genetic and/or environmental perturbations created natural genetic polymorphism, gene knock-out, gene knock-down rnai, or drug treatment. computational tools reverse-engineer or predict immune cell regulatory networks use these expression profiles.


by 2008, immgen project involved 7 immunology , 3 computational biology laboratories across united states , on 200 cell populations involved in immune system had been identified , described. consortium has created data browser explore expression patterns of particular genes, networks of co-regulated genes, , genes can reliably distinguish cell types. raw data accessible ncbi’s gene expression omnibus.








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