Mice Severe combined immunodeficiency (non-human)

-



a close-up of white severe combined immunodeficiency (scid) mouse held human hand.


scid mice routinely used model organisms research basic biology of immune system, cell transplantation strategies, , effects of disease on mammalian systems. have been extensively used hosts normal , malignant tissue transplants. in addition, useful testing safety of new vaccines or therapeutic agents in immunocompromised individuals.


the condition due rare recessive mutation on chromosome 16 responsible deficient activity of enzyme involved in dna repair (prkdc or protein kinase, dna activated, catalytic polypeptide ). because v(d)j recombination not occur, humoral , cellular immune systems fail mature. scid mice, therefore, present impaired ability make t or b lymphocytes, or activate components of complement system, , cannot efficiently fight infections, nor reject tumors , transplants.


by crossing scid mice mice carrying mutations in related genes, such interleukin-2rgamma, more efficient immunocompromised strains can created further aid research. degree various components of immune system compromised varies according other mutations mice carry along scid mutation.








Comments

Post a Comment

Popular posts from this blog

In literature Socialist realism in Romania

-
1 in literature 1.1 prose works 1.2 poetry 1.3 drama in literature the symbolic debut of socialist realism in literature, official ideology, took place in january 1948, when 3 articles signed sorin toma published in scînteia. titled poetry of putrefaction or putrefaction of poetry , dealt poetic works of tudor arghezi. language used extremely harsh , marked complete break interwar values: foul-smelling vocabulary [...], arghezi in poetry picasso did in painting, introducing excrement artistic material... 1 finds bits of real beauty here , there in arghezi s poetry. in 1950, mihai eminescu school of literature founded, aim of forming new generation of writers in romanian people s republic. in article published in viaţa românească (nr. 3 of 1951), mihai beniuc, member of writers union of romania, offered definition of socialist-realist poet: must philosopher familiar profound ideas of age [...], toward marx, engels, lenin , stalin opened way [...], , activist in service of ideas. ne...
Read more

Flipnote creation Flipnote Studio 3D

-
the main screen of flipnote creation interface. largely similar predecessor, flipnote studio 3d allows users create short animated sketches known flipnotes. flipnotes can made of hundreds of frames, , can played @ variety of speeds. software offers users option create 3d flipnotes drawing different parts of animation on 3 layers. the main tools include pen, eraser, , paintbrush. new flipnotes studio 3d tools draw shapes, fill enclosed areas (paint bucket), , insert text. application features limited color palette, including black, white, red, blue, green, , yellow. slight improvement upon flipnote studio, didn t include yellow , green selectable colors, still possible using color mixing. selection tool used copy , manipulate parts of frame. users can use 3ds system s camera , microphone add audio , photos creations. these animations can either shared on application s native online community, or exporting them gif or avi files.
Read more

How CURP codes are built Unique Population Registry Code

-
1 how curp codes built 1.1 exceptions 1.1.1 Ñ 1.1.2 common given names 1.1.3 catalog of inappropriate words how curp codes built to understand how curp codes built, 1 must first understand hispano american naming conventions. full names in spanish-speaking countries (including mexican full names) consist of 3 elements: the curp code composed of 18 characters assigned follows: the first surname s initial , first inside vowel; the second surname s initial (or letter x if, foreign nationals, person has no second surname); the first given name s initial; date of birth (2 digits year, 2 digits month, , 2 digits day); a one-letter gender indicator (h male (hombre in spanish) or m female (mujer in spanish)); a two-letter code state person born; persons born abroad, code ne (nacido en el extranjero) used; the first surname s second inside consonant; the second surname s second inside consonant; the first given name s second inside consonant; and two characters ranging 0-9 people born before...
Read more