Functions Vitamin B6

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1 functions

1.1 amino acid metabolism
1.2 glucose metabolism
1.3 lipid metabolism
1.4 hemoglobin synthesis , function
1.5 gene expression





functions

plp, metabolically active form of vitamin b6, involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis , function, , gene expression. plp serves coenzyme (cofactor) many reactions including decarboxylation, transamination, racemization, elimination, replacement, , beta-group interconversion. liver site vitamin b6 metabolism.


amino acid metabolism

glucose metabolism

plp required coenzyme of glycogen phosphorylase, enzyme necessary glycogenolysis occur. plp can catalyze transamination reactions essential providing amino acids substrate gluconeogenesis.


lipid metabolism

plp essential component of enzymes facilitate biosynthesis of sphingolipids. particularly, synthesis of ceramide requires plp. in reaction, serine decarboxylated , combined palmitoyl-coa form sphinganine, combined fatty acyl-coa form dihydroceramide. dihydroceramide further desaturated form ceramide. in addition, breakdown of sphingolipids dependent on vitamin b6 because sphingosine-1-phosphate lyase, enzyme responsible breaking down sphingosine-1-phosphate, plp-dependent.


hemoglobin synthesis , function

plp aids in synthesis of hemoglobin, serving coenzyme enzyme ala synthase. binds 2 sites on hemoglobin enhance oxygen binding of hemoglobin.


gene expression

plp has been implicated in increasing or decreasing expression of genes. increased intracellular levels of vitamin lead decrease in transcription of glucocorticoids. also, vitamin b6 deficiency leads increased gene expression of albumin mrna. also, plp influences expression of glycoprotein iib interacting various transcription factors. result inhibition of platelet aggregation.








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