8 to 3 position List of cocaine analogues

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constrained thiophene tropane note pi symmetry of partially hydrogen-unsaturated cyclopentane substitutes benzene place other tricyclic tropanes left.



tricyclic tropanes, values in ki (nm)

1st structure (di-chloro benzene, 2β-ch2ocome) sert = 1.6, dat = 1870, net = 638

2nd structure (para-bromo, meta-chloro, 2β-co2me) sert = 2.3, dat = 5420, net = 459

3rd structure (para-iodo, meta-chloro, 2β-ch2ocoph) sert = 0.06, dat/net both = >10k










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